Flexifen 5mg Tablet

✔️ Uses of

• Muscle Spasm

✔️ How does Flexifen 5mg Tablet work?

Flexifen 5mg Tablet works by inhibiting the release of certain chemicals in the brain and spinal cord, which helps to relieve pain and improve muscle movement.

✔️ Side Effects of

Common adverse reactions associated with Baclofen include drowsiness, daytime sedation, dizziness, weakness, and fatigue. Other possible side effects encompass various systems, such as the CNS, cardiovascular, gastrointestinal, and genitourinary systems.

✔️ Quick Suggestions:

• Flexifen 5mg Tablet provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system.
• Flexifen 5mg Tablet should be taken during meals with a little liquid.
• Flexifen 5mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
• Avoid consuming alcohol when taking Flexifen 5mg Tablet as it may cause excessive drowsiness.
• Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Do not stop taking it suddenly without talking to your doctor if you've been on it for a long time.

✔️ Indications:

Baclofen is prescribed for the following conditions:

• Spasticity resulting from various forms of multiple sclerosis.
• Flexor spasms and associated pain, clonus, and muscle rigidity.
• Skeletal muscle spasms due to rheumatic disorders.
• Spinal cord injuries and other spinal cord diseases.
• Cerebrovascular accidents or neoplastic or degenerative brain diseases.

✔️ Pharmacology

Flexifen 5mg Tablet works by inhibiting monosynaptic and polysynaptic reflexes in the spinal cord through the activation of GABAB receptors. This blocks the release of glutamate and aspartate. Baclofen may also induce CNS depression by acting within the spinal cord. It exhibits an antinociceptive effect.

✔️ Dosage & Administration of Flexifen 5mg Tablet

For adults and children over 10 years:

• Start with 5 mg, taken three times daily, preferably with or after food.
• Gradually increase the dosage, with a maximum of 100 mg daily.

For children under 10 years, the starting dose and maintenance dose vary by age:

• 12 months to 2 years: Start with 10-20 mg daily.
• 2 years to 6 years: Start with 20-30 mg daily.
• 6 years to 10 years: Start with 30-60 mg daily.

✔️ Interaction

Baclofen can interact with several medications and substances:

• Increased sedation may occur when taken with CNS depressants, alcohol, or synthetic opioids.
• Combined use with antihypertensive drugs may lead to a drop in blood pressure, necessitating dosage adjustments.
• Baclofen and tricyclic antidepressants may potentiate each other's effects, resulting in significant muscle hypotonia.
• In individuals with Parkinson's disease receiving Baclofen along with levodopa and carbidopa, reports of mental confusion, hallucinations, headaches, nausea, and restlessness have been documented.
• Concurrent use of MAO inhibitors with Baclofen can lead to increased CNS depressant effects.

✔️ Contraindications

Baclofen should not be used by individuals hypersensitive to any of its ingredients.

✔️ Pregnancy & Lactation

Baclofen is classified as pregnancy category B3. While it can cross the placental barrier, its safe use during pregnancy has not been definitively established. The potential benefits should be weighed against the potential risks, and its use during pregnancy should be based on the physician's judgment. Baclofen is excreted in breast milk, but available evidence suggests that the amounts are small and unlikely to harm the infant.

✔️ Precautions & Warnings

Several precautions should be observed when using Baclofen, including careful dosage adjustment in patients with impaired renal function or undergoing chronic hemodialysis. Patients with psychiatric disorders, epilepsy, or a history of these conditions should be closely monitored as exacerbations may occur. Baclofen may lower the seizure threshold, potentially causing seizures upon discontinuation or in cases of overdose. Caution is advised in individuals with peptic ulcers, cerebrovascular diseases, or hepatic, renal, or respiratory failure. Respiratory and cardiovascular function should be closely monitored, especially in patients with cardiopulmonary or respiratory muscle weakness. Baclofen may lead to improved neurogenic bladder emptying, but acute urinary retention can occur in individuals with preexisting sphincter hypertonia.

✔️ Storage Conditions

Store below 30°C, away from light and moisture, and out of the reach of children.